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Growth Hormone Research

Amino Acids Study Results Intravenous Ornithine Produces a five-fold increase in serum growth hormone in humans. Ornithine Increased serum growth hormone in bodybuilders, up to four times the baseline level.

Arginine 250 mg/kg/day of oral arginine aspartate given to five healthy subjects for seven days caused a 60% rise in GH during slow wave sleep compared to the control period. Arginine and Ornithine In a double-blind study, adult males participating in a 5-week progressive strength-training program who consumed 2 grams of L-arginine and 1 gram of L-ornithine experienced significantly higher total strength and lean body mass scores and excreted less urinary hydroxyproline than placebo-treated subjects.

Ornithine Alpha-ketoglutarate (OKG) Significantly increased IGF-1 and growth hormone levels in trauma patients. In healthy subject, OKG increased tissue levels of growth-hormone-releasing glutamine. Arginine and lysine 1200 milligrams of arginine pyroglutamate combined with L-lysine hydrochloride significantly elevated biologically active growth hormone from two to eight times the baseline value in 15 healthy male subjects aged 15 to 20 years old.

Arginine and lysine 1,500 mg arginine and 1,500 mg lysine increased GH in young men only during resting conditions.

Glycine In 19 normal, non-obese subjects, 6.75 grams of glycine increased growth hormone levels up to 300 to 400 percent that of baseline. Glycine and L-arginine Increased the subjects mean resistance to fatigue up to 28% over the controls during acute exhaustive high-intensity anaerobic isokinetic exercise and produced an overall gain in total muscle work of 10.5% more than controls.

Gamma Aminobutyric Acid (GABA) A single oral dose of 5 grams of GABA administered to 19 subjects significantly elevated plasma growth hormone levels compared to placebo-treated controls. Glutamine Two grams of oral glutamine resulted in elevated plasma growth hormone in 8 of 9 subjects tested. References:

1. Penny R, Blizzard RM, Davis T. Sequential arginine and insulin tolerance test on the same day.J Clin Endocrinol.1969;29:1499. 2. Job JC, Sizonenko PC, Balage M. Interpretation statistique des epreuves de stimulation de la secretion dhormone de croissance par linsuline et largine. Arch France Ped (Paris). 1971;28:505.

3. Mathieni G. Growth hormone secretion by arginine stimulus: the effect of both low doses and oral arginine. Boll Soc It Sper Biol. 1980;56:2254.

4. Pearson D and Shaw S. Life Extension: A Practical Scientific Approach. Warner Books. New York. 1982, pg. 289-290.

5. Bucci L, Hickson JF, Pivarnik JM, Wolinsky I, McMahon JC. Ornithine ingestion and growth hormone release in bodybuilders. Nutr Res. 1990;10:2

6. Braverman ER, Pfeiffer CC. Arginine and citrulline in the healing nutrients within. Facts, Findings and New Research on Amino Acids. Keats Publishing. New Canaan, Connecticut, 1986, pg. 173.

7. Marcell TJ, Taaffe DR, Hawkins SA, Tarpenning KM, Pyka G, et al. Oral arginine does not stimulate basal or augment exercise-induced GH secretion in either young or old adults. Journal of Gerontology. 1999;54A(8):M395-399.

8. Surninski RR, Robertson RJ, Goss FL, et al. Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men. Int J Sport Nutr. 1997;7:48-60.

9. Besset A, Bonardet A, Rondouin G, Descomps B, Passouant P. Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta Endocrinol (Copenh). 1982;99(1):18-23.

10. Elsair C. Effets de l’arginine, administrie par voie orale. C R Soc Biol. 1985;179:608.

11. Elam RP, Hardin DH, Sutton RA, Hagen L. Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males. J Sports Med Phys Fitness. 1989;29(1):52-6.

12. Di Pasquale M. Amino Acids and Proteins for the Athlete. The Anabolic Edge. CRC Press. Boca Raton. 1997, pg. 130.

13. Vaubourdolle M, Cynober L, Lioret N, Coudray-Lucas C, Aussel C, Saizy R, Giboudeau J. Influence of enterally administered ornithine alpha-ketoglutarate on hormonal patterns in burn patients. Burns Incl Therm Inj. 1987;13(5):349-56.

14.Cynober L. Ornithine alpha-ketoglutarate in nutritional support. Nutrition. 1991;7(5):313-22.

15. Jeevanandam M, Petersen SR. Substrate fuel kinetics in enterally fed trauma patients supplemented with ornithine alpha ketoglutarate. Clin Nutr. 1999;18(4):209-17.

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